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                            September 30, 2022

       Georges Gemayel, Ph.D.
       Interim President and Chief Executive Officer
       Gemini Therapeutics, Inc. /DE
       297 Boston Post Road #248
       Wayland, MA 01778

                                                        Re: Gemini
Therapeutics, Inc.
                                                            Registration
Statement on Form S-4
                                                            Filed September 2,
2022
                                                            File No. 333-267276

       Dear Dr. Gemayel:

              We have reviewed your registration statement and have the
following comments. In
       some of our comments, we may ask you to provide us with information so
we may better
       understand your disclosure.

              Please respond to this letter by amending your registration
statement and providing the
       requested information. If you do not believe our comments apply to your
facts and
       circumstances or do not believe an amendment is appropriate, please tell
us why in your
       response.

              After reviewing any amendment to your registration statement and
the information you
       provide in response to these comments, we may have additional comments.

       Registration Statement on Form S-4 filed September 2, 2022

       Cover Page

   1.                                                   We note the disclosure
on page 192 that Disc stockholders, including Disc executive
                                                        officers, directors and
other significant shareholders, who cumulatively own
                                                        approximately 90% of
outstanding Disc stock, have entered into support agreements with
                                                        Disc and Gemini, and
have agreed, following the effectiveness of the registration
                                                        statement, to execute
written consent to adopt the Merger Agreement and approve the
                                                        merger and related
transactions. "Therefore, holders of a sufficient number of shares of
                                                        Disc capital stock
required to adopt the Merger Agreement and approve the merger and
                                                        related transactions
are contractually obligated to adopt the Merger Agreement [and] are
                                                        expected to [approve]
the Merger Agreement via written consent." It appears that the
                                                        shares subject to the
support agreements/written consents are not appropriate to be
 Georges Gemayel, Ph.D.
Gemini Therapeutics, Inc. /DE
September 30, 2022
Page 2
         included in this Form S-4. Please provide us your analysis. Refer to
Securities Act Forms
         Compliance and Disclosure Interpretation (C&DI) 225.10 and Securities
Act Sections
         C&DI 139.29.
2.       Revise the cover page and summary on page 13 to disclose the estimated
1.1052 exchange
         ratio disclosed on page 178. Revise both locations to disclose the
treatment of Disc
         preferred stockholders.
3.       Revise to disclose the per share purchase price paid by the investors
in the Disc pre-
         closing financing. We note that investors in the Disc pre-closing
financing will
         receive restricted Disc shares in a private placement issued
immediately before the
         closing. Revise to clarify the treatment of these shares in the
merger.
The Companies, page 9

4.       Revise the Gemini summary to address the 2021 business combination and
to clarify its
         current status.
5.       We note the statement in the Disc summary on on page 9 that
"Bitopertin was
         previously evaluated by Roche in a comprehensive clinical program in
over 4,000
         individuals in other indications which demonstrated the activity of
bitopertin as a GlyT1
         inhibitor and effects on heme biosynthesis" and on page 10 that "Disc
submitted an IND
         for DISC-0974 in June 2021 and participants completed a Phase 1
clinical trial in healthy
         volunteers in the U.S. in June 2022 with preliminary results showing
an acceptable
         tolerability profile, as well as evidence of target engagement and
iron mobilization
         and erythropoiesis." As safety and efficacy determinations are solely
within the FDA's
         authority and they continue to be evaluated throughout all phases of
clinical trials, please
         remove these and similar references throughout the prospectus. In the
Business section,
         you may present objective data resulting from your trials without
including conclusions
         related to safety or efficacy.
Risks Related to the Merger, page 17

6.       Revise the first bullet point to clarify, if true, that the exchange
ratio calculation will not
         change based on the market price of Gemini common stock because it is
unrelated to the
         market price of Gemini common stock.
Gemini's by-laws provide that the Court of Chancery of the State of Delaware
and the federal
district
FirstNamecourts of . . . Massachusetts.
            LastNameGeorges             . ., page
                                 Gemayel,         73
                                              Ph.D.
Comapany
7.        NameGemini
      Please               Therapeutics,
              revise this risk            Inc. /DEthe risk that the exclusive
forum provisions may
                               factor to disclose
      result
September 30,in2022
                increased
                     Page costs
                            2    for investors to bring a claim.
FirstName LastName
 Georges Gemayel, Ph.D.
FirstName LastNameGeorges
Gemini Therapeutics, Inc. /DEGemayel, Ph.D.
Comapany 30,
September NameGemini
              2022      Therapeutics, Inc. /DE
September
Page 3    30, 2022 Page 3
FirstName LastName
Background of the Merger, page 136

8.       Please provide us with copies of the materials that your financial
advisor prepared and
         shared with your board in connection with this transaction, including
any board books,
         transcripts and summaries of oral presentations made to the board,
that were material to
         the board's decision to approve the merger agreement and the
transactions contemplated
         thereby.
9.       Revise the background to provide additional information regarding the
negotiations and
         elimination of other potential business combination candidates. In
doing so, please revise
         the bottom of page 136 to further clarify the proposed criteria the
board determined it
         would use to evaluate potential indications of interest. On page 137,
clarify why the
         special committee prioritized the indications of interest from Disc,
Party A and Party B
         from among the 11 companies who held management presentations, and on
what criteria
         or why discussions were terminated with 7 companies after the March 7,
2022 meeting.
         Finally, please clarify how each of the alternative entities was
finally eliminated as a
         potential merger partner.
10.      Generally revise the background section to provide further information
regarding the
         negotiations of the exchange ratio. In particular, on page 145, please
revise the first full
         paragraph to provide additional information regarding how the parties
determined the
         calculation of net cash and the exchange ratio.
Gemini's Reasons for the Merger, page 145

11.      Please clarify what the Gemini Board considered about "the regulatory
pathway for, and
         market opportunity of, Disc's product candidates" and what the Board
considered to be
         Disc's "upcoming value inflection points."
12.      Revise Gemini's reasons for the merger to clarify what consideration
the Board and
         Special Committee gave to the fact that the Financial Projections
project income for the
         extended period through 2041, where Disc has yet to commercialize a
product, and the
         financial advisor opinion and other factors on which the board and
special committee
         based their decision, utilize those extended projections.
Opinion of Gemini's Financial Advisor, page 149

13.      Revise to clarify whether the financial advisor considered the 1.1052
estimated exchange
         ratio disclosed on page 173, or some other exchange ratio in
conducting its analyses.
14.      Clarify the basis for SVB Securities relying on a discounted cash flow
analysis utilizing
         projected cash flow through 2041, in light of the development stage of
Disc's
         business, and who determined the projected range.
15.      Revise to provide additional information regarding how SVB selected
the comparable
         companies and whether it excluded any comparable companies that fit
those criteria.
 Georges Gemayel, Ph.D.
FirstName LastNameGeorges
Gemini Therapeutics, Inc. /DEGemayel, Ph.D.
Comapany 30,
September NameGemini
              2022      Therapeutics, Inc. /DE
September
Page 4    30, 2022 Page 4
FirstName LastName
Certain Unaudited Financial Projections, page 155

16.      Expand your disclosures to provide additional information surrounding
the material
         assumptions and estimates underlying the financial projections on page
156 to provide
         investors with sufficient information to evaluate the projected
financial information. For
         example:
             Please explain how the preliminary internal financial projections
provided by Disc
             were adjusted by the management of Gemini as indicated in the
first paragraph.
             Disclose whether the Board and Management considered these
projections reasonable
             considering the clinical stage operations of Disc and the extended
period of the
             projections.
             Identify the market and geographical regions for the revenue
projections and the
             specific market growth rates and projected market rate
penetrations to help provide
             additional insight into the range in these rates underlying the
revenue projections.
             Explain how the market rate growth and market rate penetrations
were determined.
             Disclose material assumptions related to acquisitions and product
development.
             Disclose any specific assumptions related to regulatory approvals.
             Clarify whether, and if so, how, the passage of time was
considered in relation to the
             nineteen-year projection period.
Tax Treatment of the Merger
Material U.S. Federal Income Tax Consequences of the Merger, page 168

17.      We note the disclosure on page 166 regarding "if" the merger qualifies
as a
         reorganization, "U.S. holders generally . . . will not recognize gain
or loss" and that you
         have discussed "certain material U.S. federal income tax consequences
of the merger that
         are applicable to U.S holders." We also note from page 168 that you
"intend" for the
         merger to qualify as a tax-free    reorganization    within the
meaning of Section 368(a) of
         the Code, but that "no opinion of counsel has been obtained or will be
obtained regarding
         the treatment of the merger as a tax-free reorganization." As the
tax-free nature of the
         transaction is material to investors, revise to provide counsel's
opinion. Refer to Item
         601(b)(8) of Regulation S-K. To the extent the opinion is subject to
uncertainty, counsel
         may provide a "should' or "more likely than not" opinion and explain
why a "will" opinion
         cannot be given and describe the degree of uncertainty. For guidance,
please refer to
         Sections III.B.2 and III.C.4 of Staff Legal Bulletin No. 19. Please
similarly revise the
         disclosure of the Material U.S. Federal Tax Consequences of the CVRs
to Holders of
         Gemini Common Stock" on page 198, and the Material U.S. Federal Tax
Consequences of
         the Reverse Stock Split on page 228. Finally, please revise the
related disclosures in the
         Prospectus Summary and elsewhere in the prospectus accordingly.
Conditions to Completion of the Merger, page 186

18.      Please revise to clarify that you have identified all material
conditions to the merger. In
         addition, identify the closing conditions that are subject to waiver
here and in the
 Georges Gemayel, Ph.D.
Gemini Therapeutics, Inc. /DE
September 30, 2022
Page 5
         related risk factor on page 24.
Disc's Pipeline, page 257

19.      Please revise your product pipeline table as follows:
             Revise to include a column for Phase 3 trials that is equally
prominent as those for
              preclinical, Phase 1 and 2.
             Revise to include the dates the IND was submitted for each product
candidate.
             Please revise the arrows in the pipeline table to accurately
reflect where each product
              candidate currently stands in development. On page 269, you
discuss the DISC-0974
              Phase 1 clinical study in healthy volunteers and then the two
Phase 1/2b clinical
              studies, one which has started and one which has not. Revise the
pipeline table to
              differentiate the arrows between CKD and MF, and to clarify that
the Phase 1 study
              was for healthy volunteers, and not specific to MF. We note the
risk factor on page
              79 that "Disc has only successfully completed on Phase 1 clinical
trial," which notes
              that Disc has initiated the BEACON Phase 2 trial and the
DISC-0974 1b/2 trial for
              patients with anemia of MF and may not submit its DISC-0974 1b/2
clinical trial in
              patients with anemia of CKD until it has submitted an IND.
         Finally, we note the last two rows in your pipeline table are for
preclinical programs for
         which you have not named a particular candidate or a particular
targeted disease. Also,
         the arrow for    Diamond-Blackfan Anemia (planned) and other
indications    appears to
         indicate that you have begun Phase 1 trials; however, your disclosure
on page 268
         states that you are "continuing to explore the potential of bitopertin
in these additional
         indications in preclinical studies." Please revise the pipeline table
to remove these
         preclinical programs or explain the basis for your belief that they
are material and should
         be included.
20.      Please increase the size of the graphics appearing in this section so
that the text is legible.
Collaborations and License Agreement
2019 Exclusive License Agreement with AbbVie Deutschland GmbH & Co. KG, page
285

21.      We note your disclosure that the royalty rates under the AbbVie
Agreement are subject to
         up to a percentage reduction "in the low double digits" for lack of a
valid claim on a
         country-by-country basis. Please revise your description of this
reduction in the royalty
         rate to a figure within ten percentage points.
Intellectual Property, page 287

22.    Please revise your intellectual property disclosure to clearly describe
on an individual or
       patent family basis the type of patent protection granted for each
product, the expiration
FirstName LastNameGeorges Gemayel, Ph.D.
       year of each patent held, and the jurisdiction of each patent. Please
clearly distinguish
Comapany   NameGemini
       between            Therapeutics,
                 owned patents           Inc.in-licensed
                                and patents   /DE        from third parties. In
this regard it may be
       useful
September  30,to2022
                 provide
                     Pagetabular
                           5     disclosure.
FirstName LastName
 Georges Gemayel, Ph.D.
FirstName LastNameGeorges
Gemini Therapeutics, Inc. /DEGemayel, Ph.D.
Comapany 30,
September NameGemini
              2022      Therapeutics, Inc. /DE
September
Page 6    30, 2022 Page 6
FirstName LastName
Note 2. Basis of Pro Forma Presentation , page 350

23.      We note that you have not reflected the reverse stock split within the
pro forma condensed
         combined financial information. Please tell us how you plan on
reflecting the reverse
         stock split prior to the effectiveness of the filing within the pro
forma financial statements
         and throughout the filing.
Note 4. Pro Forma Adjustments, page 351

24.      Reference is made to adjustment (I). Please reconcile this note to the
pro forma equity
         merger adjustments on page 347. Within your response, please explain
why the
         elimination of Gemini's historical equity carrying values does not
agree to Gemini's
         historical equity carrying values contained within the proforma
condensed balance sheet.
        We remind you that the company and its management are responsible for
the accuracy
and adequacy of their disclosures, notwithstanding any review, comments, action
or absence of
action by the staff.

       Refer to Rules 460 and 461 regarding requests for acceleration. Please
allow adequate
time for us to review any amendment prior to the requested effective date of
the registration
statement.

       You may contact Tara Harkins at (202) 551-3639 or Brian Cascio at (202)
551-3676 if
you have questions regarding comments on the financial statements and related
matters. Please
contact Conlon Danberg at (202) 551-4466 or Abby Adams at (202) 551-6902 with
any other
questions.



                                                                Sincerely,

                                                                Division of
Corporation Finance
                                                                Office of
Industrial Applications and
                                                                Services
cc:      Mark Nylen, Esq.