United States securities and exchange commission logo January 19, 2023 John Quisel, J.D., Ph.D. Chief Executive Officer Disc Medicine, Inc. 321 Arsenal Street, Suite 101 Watertown, MA 02472 Re: Disc Medicine, Inc. Registration Statement on Form S-3 Filed January 18, 2023 File No. 333-269270 Dear John Quisel: This is to advise you that we have not reviewed and will not review your registration statement. Please refer to Rules 460 and 461 regarding requests for acceleration. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Please contact Daniel Crawford at 202-551-7767 with any questions. Sincerely, Division of Corporation Finance Office of Life Sciences cc: Alicia Tschirhart, Esq.